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KMID : 0380619880200010119
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Korean Journal of Food Science and Technology
1988 Volume.20 No. 1 p.119 ~ p.124
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Desmutagenic Action of Sugar Degradation Products
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김인수/Kim, In Soo
박영호/김선봉/염동민/Park, Yeung Ho/Kim, Seon Bong/Yeum, Dong Min
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Abstract
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The desmutagenic effects of α-hydroxycarbonyl compounds, such as glyceraldehyde, glycolaldehyde, dihydroxyacetone, furfural, 5-hydroxymethylfurfural, maltol, acetol and acetoin and α-dicarbonyls, such as diacetyl, glyoxal, methyl glyoxal and 2, 3-pentanedione were investigated against the mutagenic heterocyclic amines, such as Trp-P-1, Trp-P-2, Glu-P -1, Glu-P-2 and IQ. Most of the carbonyl compounds suppressed the mutagenicity of heterocyclic amines for S. typhimurium TA98, α-dicarbonyl compounds showing a higher desmutagenic effect than α-hydroxycarbonyl compounds. Among the α-hydroxycarbonyl compounds, glyceraldehyde, glycolaldehyde and dihydroxyacetone showed more effective desmutagenicity,and diacetyl among the α-dicabonyl compounds had the highest desmutagenic effect. These carbonyl compounds alone also showed mutagenicity to S. typhimurium TA100 without S-9 mix. The reaction of carbonyl compounds with mutagenic heterocyclic amines also eliminated the mutagenicity of the former for S. typhimurium TA100.
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KEYWORD
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